| Pitcher | Wins |
| Cy Young | 511 |
| Walter Johnson | 417 |
| Grover Alexander | 373 |
| Christy Mathewson | 373 |
| Warren Spahn | 363 |
| Pud Galvin | 361 |
| Kid Nichols | 361 |
| Greg Maddux | 355 |
| Roger Clemens | 354 |
| Tim Keefe | 342 |
| Steve Carlton | 329 |
| John Clarkson | 327 |
| Eddie Plank | 326 |
| Nolan Ryan | 324 |
| Don Sutton | 324 |
| Phil Niekro | 318 |
| Gaylord Perry | 314 |
| Tom Seaver | 311 |
| Charley Radbourn | 310 |
| Mickey Welch | 309 |
| Tom Glavine | 305 |
| Randy Johnson | 303 |
| Lefty Grove | 300 |
| Early Winn | 300 |