| Year | Pitcher | National League Team | SO | Pitcher | American League Team | SO |
| 1901 | Noodles Hahn | Cincinnati | 239 | Cy Young | Boston | 158 |
| 1902 | Vic Willis | Boston | 225 | Rube Waddell | Philadelphia | 210 |
| 1903 | Christy Mathewson | New York | 267 | Rube Waddell | Philadelphia | 302 |
| 1904 | Christy Mathewson | New York | 212 | Rube Waddell | Philadelphia | 349 |
| 1905 | Christy Mathewson | New York | 206 | Rube Waddell | Philadelphia | 287 |
| 1906 | Fred Beebe | Chicago-St. Louis | 171 | Rube Waddell | Philadelphia | 196 |
| 1907 | Christy Mathewson | New York | 178 | Rube Waddell | Philadelphia | 232 |
| 1908 | Christy Mathewson | New York | 259 | Ed Walsh | Chicago | 269 |
| 1909 | Orval Overall | Chicago | 205 | Frank Smith | Chicago | 177 |
| 1910 | Earl Moore | Philadelphia | 185 | Walter Johnson | Washington | 313 |
| 1911 | Rube Marquard | New York | 237 | Ed Walsh | Chicago | 255 |
| 1912 | Grover Alexander | Philadelphia | 195 | Walter Johnson | Washington | 303 |
| 1913 | Tom Seaton | Philadelphia | 168 | Walter Johnson | Washington | 243 |
| 1914 | Grover Alexander | Philadelphia | 214 | Walter Johnson | Washington | 225 |
| 1915 | Grover Alexander | Philadelphia | 241 | Walter Johnson | Washington | 203 |
| 1916 | Grover Alexander | Philadelphia | 167 | Walter Johnson | Washington | 228 |
| 1917 | Grover Alexander | Philadelphia | 201 | Walter Johnson | Washington | 188 |
| 1918 | Hippo Vaughn | Chicago | 148 | Walter Johnson | Washington | 162 |
| 1919 | Hippo Vaughn | Chicago | 148 | Walter Johnson | Washington | 147 |
| 1920 | Grover Alexander | Philadelphia | 214 | Stan Coveleski | Cleveland | 133 |
| Year | Pitcher | National League Team | SO | Pitcher | American League Team | SO |
| 1921 | Burleigh Grimes | Brooklyn | 136 | Walter Johnson | Washington | 143 |
| 1922 | Dazzy Vance | Brooklyn | 134 | Urban Shocker | St. Louis | 149 |
| 1923 | Dazzy Vance | Brooklyn | 197 | Walter Johnson | Washington | 130 |
| 1924 | Dazzy Vance | Brooklyn | 262 | Walter Johnson | Washington | 158 |
| 1925 | Dazzy Vance | Brooklyn | 221 | Lefty Grove | Philadelphia | 116 |
| 1926 | Dazzy Vance | Brooklyn | 140 | Lefty Grove | Philadelphia | 194 |
| 1927 | Dazzy Vance | Brooklyn | 184 | Lefty Grove | Philadelphia | 174 |
| 1928 | Dazzy Vance | Brooklyn | 200 | Lefty Grove | Philadelphia | 183 |
| 1929 | Pat Malone | Chicago | 166 | Lefty Grove | Philadelphia | 170 |
| 1930 | Bill Hallahan | St. Louis | 177 | Lefty Grove | Philadelphia | 209 |
| 1931 | Bill Hallahan | St. Louis | 159 | Lefty Grove | Philadelphia | 175 |
| 1932 | Dizzy Dean | St. Louis | 191 | Red Ruffing | New York | 190 |
| 1933 | Dizzy Dean | St. Louis | 199 | Lefty Gomez | New York | 163 |
| 1934 | Dizzy Dean | St. Louis | 195 | Lefty Gomez | New York | 158 |
| 1935 | Dizzy Dean | St. Louis | 190 | Tommy Bridges | Detroit | 163 |
| 1936 | Van Lingle Mungo | Brooklyn | 238 | Tommy Bridges | Detroit | 175 |
| 1937 | Carl Hubbell | New York | 159 | Lefty Gomez | New York | 194 |
| 1938 | Clay Bryant | Chicago | 135 | Bob Feller | Cleveland | 240 |
| 1939 | Claude Passeau | Philadelphia-Chicago | 137 | Bob Feller | Cleveland | 246 |
| . | Bucky Walters | Cincinnati | 137 | . | . | . |
| 1940 | Kirby Higbe | Philadelphia | 137 | Bob Feller | Cleveland | 261 |
| Year | Pitcher | National League Team | SO | Pitcher | American League Team | SO |
| 1941 | John Vander Meer | Cincinnati | 202 | Bob Feller | Cleveland | 260 |
| 1942 | John Vander Meer | Cincinnati | 186 | Tex Hughson | Boston | 113 |
| . | . | . | . | Bobo Newsom | Washington | 113 |
| 1943 | John Vander Meer | Cincinnati | 174 | Allie Reynolds | Cleveland | 151 |
| 1944 | Bill Voiselle | New York | 161 | Hal Newhouser | Detroit | 187 |
| 1945 | Preacher Roe | Pittsburgh | 148 | Hal Newhouser | Detroit | 212 |
| 1946 | Johnny Schmitz | Cincinnati | 135 | Bob Feller | Cleveland | 348 |
| 1947 | Ewell Blackwell | Cincinnati | 193 | Bob Feller | Cleveland | 196 |
| 1948 | Harry Brecheen | St. Louis | 149 | Bob Feller | Cleveland | 164 |
| 1949 | Warren Spahn | Boston | 151 | Virgil Trucks | Detroit | 153 |
| 1950 | Warren Spahn | Boston | 191 | Bob Lemon | Cleveland | 170 |
| 1951 | Warren Spahn | Boston | 164 | Vic Raschi | New York | 164 |
| . | Don Newcombe | Los Angeles | 164 | . | . | . |
| 1952 | Warren Spahn | Boston | 183 | Allie Reynolds | New York | 160 |
| 1953 | Robin Roberts | Philadelphia | 198 | Billy Pierce | Chicago | 186 |
| 1954 | Robin Roberts | Philadelphia | 185 | Bob Turley | Baltimore | 185 |
| 1955 | Sam Jones | Chicago | 198 | Herb Score | Cleveland | 245 |
| 1956 | Sam Jones | Chicago | 176 | Herb Score | Cleveland | 263 |
| 1957 | Jack Sanford | Philadelphia | 188 | Early Wynn | Cleveland | 184 |
| 1958 | Sam Jones | St. Louis | 225 | Early Wynn | Chicago | 179 |
| 1959 | Don Drysdale | Los Angeles | 242 | Jim Bunning | Detroit | 201 |
| 1960 | Don Drysdale | Los Angeles | 246 | Jim Bunning | Detroit | 201 |
| Year | Pitcher | National League Team | SO | Pitcher | American League Team | SO |
| 1961 | Sandy Koufax | Los Angeles | 269 | Camilo Pacual | Minnesota | 221 |
| 1962 | Don Drysdale | Los Angeles | 232 | Camilo Pacual | Minnesota | 206 |
| 1963 | Sandy Koufax | Los Angeles | 306 | Camilo Pacual | Minnesota | 202 |
| 1964 | Bob Veale | Pittsburgh | 250 | Al Downing | New York | 217 |
| 1965 | Sandy Koufax | Los Angeles | 382 | Sam McDowell | Cleveland | 325 |
| 1966 | Sandy Koufax | Los Angeles | 317 | Sam McDowell | Cleveland | 225 |
| 1967 | Jim Bunning | Philadelphia | 253 | Jim Lonborg | Boston | 246 |
| 1968 | Bob Gibson | St. Louis | 268 | Sam McDowell | Cleveland | 283 |
| 1969 | Ferguson Jenkins | Chicago | 273 | Sam McDowell | Cleveland | 279 |
| 1970 | Tom Seaver | New York | 283 | Sam McDowell | Cleveland | 304 |
| 1971 | Tom Seaver | New York | 289 | Mickey Lolich | Detroit | 308 |
| 1972 | Steve Carlton | Philadelphia | 310 | Nolan Ryan | California | 329 |
| 1973 | Tom Seaver | New York | 251 | Nolan Ryan | California | 383 |
| 1974 | Steve Carlton | Philadelphia | 240 | Nolan Ryan | California | 367 |
| 1975 | Tom Seaver | New York | 243 | Frank Tanana | California | 269 |
| 1976 | Tom Seaver | New York | 235 | Nolan Ryan | California | 327 |
| 1977 | Phil Niekro | Atlanta | 262 | Nolan Ryan | California | 341 |
| 1978 | J.R. Richard | Houston | 303 | Nolan Ryan | California | 260 |
| 1979 | J.R. Richard | Houston | 313 | Nolan Ryan | California | 223 |
| 1980 | Steve Carlton | Philadelphia | 286 | Len Barker | Cleveland | 187 |
| Year | Pitcher | National League Team | SO | Pitcher | American League Team | SO |
| 1981 | Fernando Valenzuela | Los Angeles | 180 | Len Barker | Cleveland | 127 |
| 1982 | Steve Carlton | Philadelphia | 286 | Floyd Bannister | Seattle | 209 |
| 1983 | Steve Carlton | Philadelphia | 275 | Jack Morris | Detroit | 232 |
| 1984 | Dwight Gooden | New York | 276 | Mark Langston | Seattle | 204 |
| 1985 | Dwight Gooden | New York | 268 | Bert Blyleven | Cleveland-Minnesota | 206 |
| 1986 | Mike Scott | Houston | 306 | Mark Langston | Seattle | 245 |
| 1987 | Nolan Ryan | Houston | 270 | Mark Langston | Seattle | 262 |
| 1988 | Nolan Ryan | Houston | 228 | Roger Clemens | Boston | 291 |
| 1989 | Jose DeLeon | St. Louis | 201 | Nolan Ryan | Texas | 291 |
| 1990 | David Cone | New York | 233 | Nolan Ryan | Texas | 301 |
| 1991 | David Cone | New York | 241 | Roger Clemens | Boston | 241 |
| 1992 | John Smoltz | Atlanta | 215 | Randy Johnson | Seattle | 241 |
| 1993 | Jose Rijo | Cincinnati | 227 | Randy Johnson | Seattle | 308 |
| 1994 | Andy Benes | San Diego | 189 | Randy Johnson | Seattle | 204 |
| 1995 | Hideo Nomo | Los Angeles | 236 | Randy Johnson | Arizona | 294 |
| 1996 | John Smoltz | Atlanta | 276 | Roger Clemens | Boston | 257 |
| 1997 | Curt Schilling | Philadelphia | 319 | Roger Clemens | Toronto | 292 |
| 1998 | Curt Schilling | Philadelphia | 300 | Roger Clemens | Toronto | 271 |
| 1999 | Randy Johnson | Arizona | 364 | Pedro Martinez | Boston | 313 |
| 2000 | Randy Johnson | Arizona | 347 | Pedro Martinez | Boston | 284 |
| Year | Pitcher | National League Team | SO | Pitcher | American League Team | SO |
| 2001 | Randy Johnson | Arizona | 372 | Hideo Nomo | Boston | 220 |
| 2002 | Randy Johnson | Arizona | 334 | Pedro Martinez | Boston | 239 |
| 2003 | Kerry Wood | Chicago | 266 | Esteban Loaiza | Chicago | 207 |
| 2004 | Randy Johnson | Arizona | 290 | Johan Santana | Minnesota | 265 |
| 2005 | Jake Peavy | San Diego | 216 | Johan Santana | Minnesota | 238 |
| 2006 | Aaron Harang | Cincinnati | 216 | Johan Santana | Minnesota | 245 |
| 2007 | Jake Peavy | San Diego | 240 | Scott Kazmir | Tampa Bay | 239 |
| 2008 | Tim Lincecum | San Francisco | 265 | A.J. Burnett | Toronto | 231 |
| 2009 | Tim Lincecum | San Francisco | 261 | Justin Verlander | Detroit | 269 |
| 2010 | Tim Lincecum | San Francisco | 231 | Jered Weaver | Los Angeles | 250 |
| 2011 | Clayton Kershaw | Los Angeles | 248 | Justin Verlander | Detroit | 250 |
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